HMBS Protein (AA 1-361) (His tag)

Produktnummer ABIN667690

Produktdetails

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-361

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HMBS Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: HMBS, 1-361aa , Human, His tag, E.coli

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol, 0.1M NaCl

Lagerung: 4 °C

Antigendetails

Target: HMBS (Hydroxymethylbilane Synthase (HMBS))

Andere Bezeichnung: HMBS (HMBS Produkte)

Synonyme: PBG-D Protein, PBGD Protein, PORC Protein, UPS Protein, URO-S Protein, hemC Protein, pbg-d Protein, pbgd Protein, ups Protein, SPAC806.01 Protein, DDBDRAFT_0186148 Protein, DDBDRAFT_0231417 Protein, DDB_0186148 Protein, DDB_0231417 Protein, Hmbs Protein, NV50236 Protein, T25658 Protein, Ups Protein, Uros1 Protein, hmbs Protein, zgc:64128 Protein, hmbsl Protein, id:ibd5004 Protein, im:7140060 Protein, zgc:110690 Protein, hydroxymethylbilane synthase Protein, hydroxymethylbilane synthase S homeolog Protein, hydroxymethylbilane synthase L homeolog Protein, hydroxymethylbilane synthase (predicted) Protein, Hydroxymethylbilane synthase Protein, hydroxymethylbilane synthase a Protein, hydroxymethylbilane synthase, b Protein, HMBS Protein, Hmbs Protein, hmbs Protein, hmbs.2.S Protein, hmbs.L Protein, CNC02250 Protein, hem3 Protein, hemC Protein, Trad_0335 Protein, Plabr_2100 Protein, Sgly_3113 Protein, SMLT_RS19660 Protein, PMI_RS16580 Protein, hmbsa Protein, hmbsb Protein

Hintergrund: Porphobilinogen deaminase, also known as HMBS, is a member of the hydroxymethylbilane synthase superfamily. It is a cytoplasmic enzyme found in the heme synthesis pathway. Deficiency of HMBS causes errors in pyrrole metabolism which in turn leads to an inherited autosomal disorder called acute intermittent porphyria (AIP) which is characterized by acute attacks of neurological dysfunctions with hypertension, tachycardia, peripheral neurologic disturbances, abdominal pain and excessive amounts of aminolevulinic acid and porphobilinogen in the urine. Recombinant human HMBS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: PBG-D, PBGD, PORC, UPS. NCBI no.: NP_000181

Molekulargewicht: 41.9kDa (385aa) confirmed by MALDI-TOF