TCEB1 Protein (AA 1-112) (His tag)

Produktnummer ABIN667648

Produktdetails

Target: TCEB1 (Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) (TCEB1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-112

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses TCEB1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: TCEB1, 1-112 aa, Human, His tag E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol, 1mM DTT, 0.15M NaCl.

Lagerung: 4 °C

Antigendetails

Target: TCEB1 (Transcription Elongation Factor B (SIII), Polypeptide 1 (15kDa, Elongin C) (TCEB1))

Andere Bezeichnung: TCEB1 (TCEB1 Produkte)

Synonyme: 2610043E24Rik Protein, 2610301I15Rik Protein, AA407206 Protein, AI987979 Protein, AW049146 Protein, SIII Protein, eloC Protein, TCEB1 Protein, fb09f09 Protein, wu:fb09f09 Protein, zgc:111990 Protein, zgc:92635 Protein, elongin C Protein, elongin C L homeolog Protein, transcription elongation factor B (SIII), polypeptide 1b Protein, Eloc Protein, eloc.L Protein, ELOC Protein, tceb1b Protein

Hintergrund: TCEB1 (elongin C) is a subunit of elongin, which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template encoded arresting sites. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau(VHL) tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Recombinant human TCEB1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Transcription elongation factor B polypeptide 1, SIII, Elongin-C. NCBI no.: NP_005639

Molekulargewicht: 14.6 kDa (132aa), confirmed by MALDI-TOF

Pathways: SARS-CoV-2 Protein Interaktom