RGS17
Spezies: Human
Wirt: Tobacco (Nicotiana tabacum)
Recombinant
>80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, SDS, WB
RGS17 Protein, zgc:92802 Protein, MGC179306 Protein, RGS-17 Protein, RGSZ2 Protein, hRGS17 Protein, 6430507P11Rik Protein, Rgsz2 Protein, regulator of G protein signaling 17 Protein, regulator of G-protein signaling 17 Protein, RGS17 Protein, Rgs17 Protein, rgs17 Protein
Hintergrund
RGS17, also known as regulator of G-protein signaling 17, attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. It plays an important role in termination of signalling by mu opioid receptors and development of tolerance to opioid analgesic drugs. Recombinant human RGS17 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. Synonyms: Regulator of G-protein signaling 17, hRGS17, RGS-17, RGSZ2. NCBI no.: NP_036551
Molekulargewicht
26.5 kDa(230aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)