QPRT Protein (AA 1-297) (His tag)

Produktnummer ABIN667206

Produktdetails

Target: QPRT (Quinolinate Phosphoribosyltransferase (QPRT))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-297

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses QPRT Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: QPRT, 1-297aa, Human, His tag, E.coli

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol

Lagerung: 4 °C

Antigendetails

Target: QPRT (Quinolinate Phosphoribosyltransferase (QPRT))

Andere Bezeichnung: QPRT (QPRT Produkte)

Synonyme: ECK0108 Protein, JW0105 Protein, VF2184 Protein, QPRTase Protein, 2410027J01Rik Protein, AI647766 Protein, quinolinate phosphoribosyltransferase Protein, nicotinate-nucleotide pyrophosphorylase Protein, nicotinate-nucleotide diphosphorylase Protein, carboxylating Protein, ECs0113 Protein, nadC Protein, VP2522 Protein, STY0167 Protein, BJE04_RS13210 Protein, QPRT Protein, Qprt Protein

Hintergrund: Quinolinate phosphoribosyltransferase, also known as QPRT, is a major enzyme in the catabolism of quinolinate. It is an intermediate in the tryptophannicotinamide adenine dinucleotide (NAD) pathway, leading to the production of nicotinic acid, carbon dioxide and pyrophosphate. Elevation of QPRT levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Recombinant human QPRT protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: Nicotinate nucleotide pyrophosphorylase carboxylating, Quinolinate phosphoribosyltransferase , QPRTase, QAPRTase. NCBI no.: NP_055113

Molekulargewicht: 32.9 kDa (317aa), confirmed by MALDI-TOF