SGTA Protein (AA 1-313) (His tag)

Produktnummer ABIN666980

Produktdetails

Target: SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-313

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses SGTA Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Produktmerkmale: SGTA, 1-313 aa, Human, His-tagged, Recombinant, E.coli

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer(pH 8.0) containing 10% glycerol 1mM DTT.

Lagerung: 4 °C

Antigendetails

Target: SGTA (Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, alpha (SGTA))

Andere Bezeichnung: SGTA (SGTA Produkte)

Synonyme: sgta Protein, SGTA Protein, zgc:92462 Protein, SGT Protein, alphaSGT Protein, hSGT Protein, 5330427H01Rik Protein, AI194281 Protein, D10Ertd190e Protein, Sgt Protein, Stg Protein, small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha Protein, small glutamine rich tetratricopeptide repeat containing alpha Protein, small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta Protein, small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha L homeolog Protein, sgta Protein, SGTA Protein, sgtb Protein, sgta.L Protein, Sgta Protein

Hintergrund: SGTA, also known as SGT or hSGT, is a ubiquitously expressed protein that contains three TPR protein-protein interaction repeats. This protien is believed to function as a component of the androgen receptor (AR)-chaperone-cochaperone complex, acting as a cochaperone involved in androgen signaling. In addition, SGTA functions as a cochaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. On the basis of its role in apoptosis and androgen signaling, SGTA is a potential candidate for PCOS (polycystic ovary syndrome), a disorder characterized by androgen excess, obesity and menstrual disturbances. Recombinant SGTA protein, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: alphaSGT, hSGT, SGT, Small glutamine-rich tetratricopeptide repeat-containing protein alpha Small glutamine rich tetratricopeptide repeat TPR containing alpha, UBP, Vpu binding protein. NCBI no.: NP_003012

Molekulargewicht: 35.1 kDa (321aa), confirmed by MALDI-TOF