14-3-3 sigma/SFN Protein (AA 1-248)

Produktnummer ABIN666918

Produktdetails

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-248

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Produktmerkmale: 14-3-3 sigma, 1-248aa, Human, E.coli

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 50mM NaCl, 10% glycerol

Lagerung: 4 °C

Antigendetails

Target: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Andere Bezeichnung: 14-3-3 sigma (SFN Produkte)

Synonyme: YWHAS Protein, Er Protein, Mme1 Protein, Ywhas Protein, stratifin Protein, SFN Protein, Sfn Protein

Hintergrund: 14-3-3 sigma ,also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. Recombinant human 14-3-3 sigma was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: stratifin, Epithelial cell marker protein 1, HME1, YWHAS, SFN, 14-3-3 sigma. NCBI no.: NP_006133

Molekulargewicht: 27.7 kDa (248aa), confirmed by MALDI-TOF.

Pathways: p53 Signalweg, Myometrial Relaxation and Contraction