Ataxin 3 Protein (ATXN3) (AA 1-370)

Produktnummer ABIN666777

Produktdetails

Target: Ataxin 3 (ATXN3)

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-370

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Produktmerkmale: Ataxin 3 , 1-370aa, Human, Recombinant, E.coli

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In 20 mM Tris-HCl buffer (pH 7.5) containing 2mM DTT, 50mM NaCl, 10% glycerol.

Lagerung: 4 °C

Antigendetails

Target: Ataxin 3 (ATXN3)

Andere Bezeichnung: Ataxin 3 (ATXN3 Produkte)

Synonyme: Mjd Protein, zgc:56323 Protein, ATXN3 Protein, at3 Protein, jos Protein, mjd Protein, atx3 Protein, mjd1 Protein, sca3 Protein, ataxin-3 Protein, MJD1 Protein, MGC83584 Protein, AT3 Protein, ATX3 Protein, JOS Protein, MJD Protein, SCA3 Protein, 2210008M02Rik Protein, AI463012 Protein, AI647473 Protein, Sca3 Protein, Rsca3 Protein, ataxin 3 Protein, ataxin 3 L homeolog Protein, ataxin-3 Protein, atxn3 Protein, ATXN3 Protein, atxn3.L Protein, MICPUN_104046 Protein, MICPUCDRAFT_46658 Protein, Atxn3 Protein

Hintergrund: Ataxin 3 is also known as Machado-Joseph disease protein 1. Machado–Joseph disease is one of several hereditary autosomal dominant neurodegenerative disorders. This protein contains trinucleotide CAG repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. Ataxin 3 interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators. Also, ataxin-3 is a proteasome-associated factor that mediates the degradation of ubiquitinated proteins. Recombinant human Ataxin-3 was expressed in E.coli and purified by using conventional chromatography. Synonyms: Ataxin 3, ATX3, MJD, MJD1, SCA3, ATXN3, JOS, ATXN3, AT3, EC 3.4.22., Josephin, Machado Joseph disease, Machado Joseph disease protein 1, Machado-Joseph disease protein 1 homolog, MJD gene, Rsca3, SCA3 gene, Spinocerebellar ataxia type 3 protein,. NCBI no.: AAH33711

Molekulargewicht: 42.4 kDa (370aa), confirmed by MALDI-TOF.