ITGA4/ITGB7 Protein (AA 34-977) (His tag)
ITGA4 / ITGB7
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
-
- Target Alle ITGA4/ITGB7 (ITGA4 / ITGB7) Produkte
- ITGA4/ITGB7 (ITGA4 / ITGB7) (Integrin Alpha4-Beta7 (ITGA4 / ITGB7))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 34-977
- Spezies
- Human
- Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses ITGA4/ITGB7 Protein ist gelabelt mit His tag.
- Sequenz
- AA 34-977
- Reinheit
- >90 % as determined by SDS-PAGE.
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
-
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Buffer
- 50 mM Tris, 100 mM NaCl, pH 7.5
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
-
- Target
- ITGA4/ITGB7 (ITGA4 / ITGB7) (Integrin Alpha4-Beta7 (ITGA4 / ITGB7))
- Andere Bezeichnung
- Integrin alpha 4 beta 7 (ITGA4 / ITGB7 Produkte)
- Synonyme
- CD49D Protein, integrin alpha 4 Protein, Itga4 Protein
- Hintergrund
- Integrin alpha 4 beta 7 is an integrin family adhesion receptor that shares subunits with alpha 4 beta 1 (VLA4) and the E-Cadherin receptor, alpha E beta 7 . Integrin alpha 4 beta 7, which is critical for homing to intestinal mucosa, is induced during T cell activation in Peyer's patches or mesenteric lymph nodes.Its expression requires signals from local dendritic and stromal cells, including secreted retinoic acid. The HIV-1 envelope protein gp120 binds to the active form of Integrin alpha 4 beta 7, and this may or may not account for the concentration of HIV-1 virus in the gut-associated lymphoid tissue (GALT). Integrin alpha 4 beta 7 may also be involved in lymphocyte trafficking in acute intestinal graft vs. host disease (GVHD).
- Molekulargewicht
- 111.4 kDa (ITGA4) & 81.8 kDa (ITGB7)
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