BTNL2 Protein (AA 26-457) (Fc Tag)

Produktnummer ABIN6253435

Produktdetails

Target: BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 26-457

Spezies: Maus

Quelle: CHO Cells

Aufreinigungstag / Konjugat: Dieses BTNL2 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: BTNL2 (mouse):Fc (mouse) (rec.)

Spezifität: The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a.

Produktmerkmale: Protein. The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: CHO cells. Endotoxin content: <0.06EU/μg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.

Reinheit: >98 % (SDS-PAGE)

Endotoxin-Niveau: <0.06EU/μg protein (LAL test, Lonza).

Biological Activity Comment: A butyrophilin-like molecule that functions to inhibit T cell activation.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: BTNL2 (Butyrophilin-Like 2 (MHC Class II Associated) (BTNL2))

Andere Bezeichnung: BTNL2 (BTNL2 Produkte)

Synonyme: BTL-II Protein, HSBLMHC1 Protein, SS2 Protein, Ng9 Protein, BTLN2 Protein, Btl2 Protein, Gm315 Protein, NG9 Protein, BTNL2 Protein, butyrophilin like 2 Protein, butyrophilin-like 2 Protein, butyrophilin-like 2 (MHC class II associated) Protein, butyrophilin-like protein 2 Protein, BTNL2 Protein, Btnl2 Protein, LOC100348151 Protein

Hintergrund:

Alternate Names/Synonyms: Butyrophilin-like Protein 2

Product Description: Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis, to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.

NCBI Accession: NP_524574