LYVE1 Protein (AA 24-228) (Fc Tag)

Produktnummer ABIN6253331

Produktdetails

Target: LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-228

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses LYVE1 Protein ist gelabelt mit Fc Tag.

Verwendungszweck: LYVE-1 (mouse):Fc (mouse) (rec.)

Spezifität: The extracellular domain of mouse LYVE-1 (aa 24-228) is fused to the N-terminus of the Fc region of mouse IgG2a.

Produktmerkmale: Protein. The extracellular domain of mouse LYVE-1 (aa 24-228) is fused to the N-terminus of the Fc region of mouse IgG2a. Source: HEK 293 cells. Endotoxin content: <5EU/mg protein (LAL test, Lonza). Lyophilized from 0.2μm-filtered solution in PBS. Purity: >98 % (SDS-PAGE). Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-  kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia. LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium.

Reinheit: >98 % (SDS-PAGE)

Endotoxin-Niveau: <5EU/mg protein (LAL test, Lonza).

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized from 0.2μm-filtered solution in PBS.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Antigendetails

Target: LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE1))

Andere Bezeichnung: LYVE-1 (LYVE1 Produkte)

Synonyme: LYVE1 Protein, XLKD1 Protein, CRSBP-1 Protein, HAR Protein, LYVE-1 Protein, 1200012G08Rik Protein, Crsbp-1 Protein, Lyve-1 Protein, Xlkd1 Protein, lymphatic vessel endothelial hyaluronic receptor 1a Protein, lymphatic vessel endothelial hyaluronan receptor 1 Protein, lyve1a Protein, LYVE1 Protein, Lyve1 Protein

Hintergrund:

Alternate Names/Synonyms: Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1

Product Description: Lymphatic Vessel Endothelial Hyaluronan (HA) Receptor-1 (LYVE-1) is a 60-  kDa type I transmembrane glycoprotein that is a member of the Link Protein superfamily. HA is found in the extracellular matrix of most animal tissues and in body fluids. It modulates cell behavior and functions during tissue remodeling, development, homeostasis, and disease. It is often used as a marker of lymphatic endothelia. LYVE-1 is expressed on both the lumenal and ablumenal surfaces of lymphatic endothelium, and also on hepatic blood sinusoidal endothelia. This expression pattern, combined with studies showing that LYVE-1 can support cellular HA internalization in vitro, may suggest LYVE-1 participation in HA internalization for degradation, or transport of HA from tissues into the lumen of lymphatic vessels. LYVE-1-directed HA localization to lymphatic surfaces might also affect aspects of the immune response or tumor metastases. HA binding to CD44 can still occur in the presence of LYVE-1 in vitro. Therefore, LYVE-1-directed HA localization to lymphatics could provide a substrate for transmigrating CD44+ leukocytes or tumor cells. In addition to hepatic and lymphatic endothelia, some expression of LYVE-1 has been reported on Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium.

Molekulargewicht: ~70kDa (SDS-PAGE)

NCBI Accession: NP_444477

Pathways: Glycosaminoglycan Metabolic Process