MIA Protein

Produktnummer ABIN622772

Produktdetails

Target: MIA (Melanoma Inhibitory Activity (MIA))

Protein-Typ: Recombinant

Spezies: Human

Wirt: Bitte anfragen

Sequenz: Agrees with the sequence of native human MIA with an addition N-terminal Methionine residue. MGPMPKLADR KLCADQECSS HPISMAVALQ DYMAPDCRFL TIHRGQVVYV FSLKGRGRFL WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKVDVKTDKW DFYCQ

Produktmerkmale: Recombinant Human Melanoma Inhibitory Activity Protein

Reinheit: > 95.0 % as determined by: 1) Analysis by RP-HPLC. 2) Analysis by SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: The protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Potassium-phosphate pH 7.0 and 150mM potassium chloride.It is recommended to reconstitute the lyophilized Melanoma Inhibitory Activity in sterile 18MO-cm H 2 O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

Lagerung: -20 °C

Antigendetails

Target: MIA (Melanoma Inhibitory Activity (MIA))

Andere Bezeichnung: Melanoma Inhibitory Activity Protein (MIA Produkte)

Synonyme: CD-RAP Protein, Mia1 Protein, Cdrap Protein, zgc:194157 Protein, mia Protein, CDRAP Protein, Fdp Protein, MIA Protein, MIAL Protein, melanoma inhibitory activity Protein, otoraplin Protein, cilia and flagella associated protein 100 Protein, MIA Protein, Mia Protein, mia Protein, Otor Protein, CFAP100 Protein

Hintergrund: Melanoma Inhibitory Activity Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain consisting of 108 amino having a total molecular mass of 12237 Dalton. The MIA is purified by proprietary chromatographic techniques. Introduction: The Melanoma Inhibitory protein (MIA) was identified as an inhibitor of in vitro growth of malignant melanoma cells. The protein contains a SH3 domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion. In a study of human melanoma cell lines with different metastatic capacity MIA mRNA expression appeared to be inversely correlated with pigmentation. MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas. Synonyms: Melanoma-derived growth regulatory protein precursor, Cartilage-derived retinoic acid-sensitive protein, CD-RAP, MIA.