VHLL Protein (AA 1-154) (His tag)

Produktnummer ABIN620853

Produktdetails

Target: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-154

Spezies: Human

Wirt: Bitte anfragen

Aufreinigungstag / Konjugat: Dieses VHLL Protein ist gelabelt mit His tag.

Sequenz: MGSSHHHHHH SSGLVPRGSH MPRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGPEESGPEELGA EEEMEAGRPR PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR DAGTHDGLLV NQTELFVPSL NVDGQPIFAN ITLP.

Produktmerkmale: Recombinant Human Von Hippel-Lindau Protein

Reinheit: > 95.0 % as determined by SDS-PAGE.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The Von Hippel-Lindau Protein contains 1x PBS pH-7.4, 2mM EDTA, and 1mM DTT.

Lagerung: 4 °C

Antigendetails

Target: VHLL (Von Hippel-Lindau Tumor Suppressor-Like (VHLL))

Andere Bezeichnung: Von Hippel-Lindau Protein (VHLL Produkte)

Synonyme: VHLP Protein, VLP Protein, VHL like Protein, VHLL Protein

Hintergrund: Recombinant Human Von Hippel-Lindau Protein b-domain produced in E. coli is a single, non-glycosylated polypeptide chain containing 174 AA (1-154) and having a molecular mass of 19.2 kDa. The Von Hippel-Lindau antigen is fused to 20 AA His-Tag at N-terminus and purified by proprietary chromatography techniques. Introduction: Von Hippel-Lindau disease is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in b sheet (b-domain) and a smaller a-helical domain (a-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF). Synonyms: Von Hippel-Lindau disease tumor suppressor, pVHL, Protein G7, VHL, RCA1, VHL1, HRCA1.