N-Cadherin Protein (AA 160-724) (His tag)

Produktnummer ABIN5854951

Produktdetails

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 160-724

Spezies: Human

Quelle: Baculovirus infected Insect Cells

Aufreinigungstag / Konjugat: Dieses N-Cadherin Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: ADPDWVIPPI NLPENSRGPF PQELVRIRSD RDKNLSLRYS VTGPGADQPP TGIFIINPIS GQLSVTKPLD REQIARFHLR AHAVDINGNQ VENPIDIVIN VIDMNDNRPE FLHQVWNGTV PEGSKPGTYV MTVTAIDADD PNALNGMLRY RIVSQAPSTP SPNMFTINNE TGDIITVAAG LDREKVQQYT LIIQATDMEG NPTYGLSNTA TAVITVTDVN DNPPEFTAMT FYGEVPENRV DIIVANLTVT DKDQPHTPAW NAVYRISGGD PTGRFAIQTD PNSNDGLVTV VKPIDFETNR MFVLTVAAEN QVPLAKGIQH PPQSTATVSV TVIDVNENPY FAPNPKIIRQ EEGLHAGTML TTFTAQDPDR YMQQNIRYTK LSDPANWLKI DPVNGQITTI AVLDRESPNV KNNIYNATFL ASDNGIPPMS GTGTLQIYLL DINDNAPQVL PQEAETCETP DPNSINITAL DYDIDPNAGP FAFDLPLSPV TIKRNWTITR LNGDFAQLNL KIKFLEAGIY EVPIIITDSG NPPKSNISIL RVKVCQCDSN GDCTDVDRIV GAGLGTGAHH HHHH

Reinheit: > 90 % by SDS - PAGE

Endotoxin-Niveau: < 1.0 EU per 1ug of protein (determined by LAL method)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Liquid. In Phosphate Buffered Saline (  pH 7.4) containing 20 % glycerol.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: N-Cadherin (CDH2) (Cadherin 2 (CDH2))

Andere Bezeichnung: CDH2 (CDH2 Produkte)

Synonyme: CD325 Protein, CDHN Protein, CDw325 Protein, NCAD Protein, N-cadherin Protein, cadherin-2 Protein, cdhn Protein, ncad Protein, cdw325 Protein, CDH2 Protein, Cadherin-2 Protein, Ncad Protein, glo Protein, lyr Protein, pac Protein, wu:fb47h04 Protein, cadherin 2 Protein, cadherin 2 S homeolog Protein, cadherin 2, type 1, N-cadherin (neuronal) Protein, CDH2 Protein, cdh2.S Protein, cdh2 Protein, Cdh2 Protein

Hintergrund: CDH2, also known as cadherin-2 isoform 1, is a transmembrane, homophilic glycoprotein belonging to the calcium-dependent cell adhesion molecule family. It plays a role in neurons and later was found to also play a role in cardiac muscle and in cancer metastasis. Its loss promotes tumorigenesis by releasing membrane-bound B-catenin, hence stimulating Wnt signaling. It seems to be involved in tumor development, but this finding is limited in adrenocortical tumors (ACTs). Recombinant human CDH2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Molekulargewicht: 62.9kDa (574aa) 70-100kDa (SDS-PAGE under reducing conditions)

NCBI Accession: NP_001783

UniProt: P19022

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane