HCV E2 Protein (AA 482-671) (His tag)
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- Target Alle HCV E2 Proteine anzeigen
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 482-671
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Spezies
- Hepatitis C Virus (HCV)
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Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses HCV E2 Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Sequenz
- MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSERPY CWHYPPRPCG IVPAKSVCGP VYCFTPSPVV VGTTDRSGAP TYSWGANDTD VFVLNNTRPP LGNWFGCTWM NSTGFTKVCG APPCVIGGVG NNTLLCPTDC FRKHPEATYS RCGSGPWITP RCMVDYPYRL WHYPCTINYT IFKVRMYVGG VEHRLEAACN WTRGERCDLE DRDRSELSPL LLSTTQ
- Reinheit
- > 80 % by SDS - PAGE
- Top Product
- Discover our top product HCV E2 Protein
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Denatured
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M urea, 10 % glycerol
- Lagerung
- 4 °C,-20 °C,-80 °C
- Informationen zur Lagerung
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- HCV E2 (Hepatitis C Virus Envelope Protein E2 (HCV E2))
- Andere Bezeichnung
- HCV-E2 (HCV E2 Produkte)
- Substanzklasse
- Viral Protein
- Hintergrund
- E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. Recombinant HCV(Hepatitis C Virus) E2 protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molekulargewicht
- 25.4 kDa (226aa)
- NCBI Accession
- NP_671491
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