LMX1B Protein (AA 1-395) (His tag)

Produktnummer ABIN5853769

Produktdetails

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-395

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses LMX1B Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSMDIATGP ESLERCFPRG QTDCAKMLDG IKMEEHALRP GPATLGVLLG SDCPHPAVCE GCQRPISDRF LMRVNESSWH EECLQCAACQ QALTTSCYFR DRKLYCKQDY QQLFAAKCSG CMEKIAPTEF VMRALECVYH LGCFCCCVCE RQLRKGDEFV LKEGQLLCKG DYEKEKDLLS SVSPDESDSV KSEDEDGDMK PAKGQGSQSK GSGDDGKDPR RPKRPRTILT TQQRRAFKAS FEVSSKPCRK VRETLAAETG LSVRVVQVWF QNQRAKMKKL ARRHQQQQEQ QNSQRLGQEV LSSRMEGMMA SYTPLAPPQQ QIVAMEQSPY GSSDPFQQGL TPPQMPGNDS IFHDIDSDTS LTSLSDCFLG SSDVGSLQAR VGNPIDRLYS MQSSYFAS

Reinheit: > 80 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Denatured

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: iquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol, 0.4M urea

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Andere Bezeichnung: LMX1B (LMX1B Produkte)

Synonyme: LMX1.2 Protein, NPS1 Protein, LMX Protein, LMX1 Protein, LMX1.1 Protein, lmx1b Protein, lmx1b.1 Protein, Xlmx1b Protein, lmx1b.2 Protein, LIM homeobox transcription factor 1 beta Protein, LIM homeobox transcription factor 1, beta b Protein, LIM homeobox transcription factor 1, beta, gene 1 S homeolog Protein, LIM homeobox transcription factor 1, beta a Protein, LMX1B Protein, Lmx1b Protein, lmx1bb Protein, lmx1b.1.S Protein, lmx1ba Protein

Hintergrund: LMX1B is a member of LIM-homeodomain family of proteins containing two N-terminal zinc-binding LIM domains, 1 homeodomain, and a C-terminal glutamine-rich domain. It functions as a transcription factor, and is essential for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. Mutations in this gene are associated with nail-patella syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human LMX1B protein, fused to His-tag at N-terminus, was expressed in E.coli .

Molekulargewicht: 46.5 kDa (418 aa)

NCBI Accession: NP_002307

UniProt: O60663

Pathways: Dopaminergic Neurogenesis