IYD Protein (AA 24-214) (His tag)

Produktnummer ABIN5853588

Produktdetails

Target: IYD (Iodotyrosine Deiodinase (IYD))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-214

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses IYD Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSDRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE

Reinheit: > 90 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Denatured

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M uREA, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: IYD (Iodotyrosine Deiodinase (IYD))

Andere Bezeichnung: IYD (IYD Produkte)

Synonyme: MGC85450 Protein, C6orf71 Protein, DEHAL1 Protein, TDH4 Protein, dJ422F24.1 Protein, 0610009A07Rik Protein, AI265638 Protein, Dehal1 Protein, RGD1309288 Protein, IYD-1 Protein, iodotyrosine deiodinase Protein, iodotyrosine deiodinase L homeolog Protein, IYD Protein, iyd.L Protein, iyd Protein, Iyd Protein

Hintergrund: IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. Recombinant human IYD protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 25.1kDa (214aa)

NCBI Accession: NP_001158167

UniProt: Q6PHW0

Pathways: Thyroid Hormone Synthesis