PABPN1 Protein (AA 119-306) (His tag)

Produktnummer ABIN5853467

Produktdetails

Target: PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 119-306

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PABPN1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSLEAIKAR VREMEEEAEK LKELQNEVEK QMNMSPPPGN AGPVIMSIEE KMEADARSIY VGNVDYGATA EELEAHFHGC GSVNRVTILC DKFSGHPKGF AYIEFSDKES VRTSLALDES LFRGRQIKVI PKRTNRPGIS TTDRGFPRAR YRARTTNYNS SRSRFYSGFN SRPRGRVYRG RARATSWYSP Y

Reinheit: > 95 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Denatured

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: PABPN1 (Poly A Binding Protein Nuclear 1 (PABPN1))

Andere Bezeichnung: PABPN1 (PABPN1 Produkte)

Synonyme: OPMD Protein, PAB2 Protein, PABII Protein, PABP-2 Protein, PABP2 Protein, Pabp3 Protein, mPABII Protein, ARABIDOPSIS POLY(A) BINDING 2 Protein, ATPAB2 Protein, F28A23.130 Protein, F28A23_130 Protein, POLY(A) BINDING PROTEIN 2 Protein, POLY(A)-BINDING PROTEIN 2 Protein, poly(A) binding protein 2 Protein, opmd Protein, pab2 Protein, pabp2 Protein, pabpii Protein, pabpn1 Protein, Pabpn1 Protein, Poly(A)-binding protein 2 Protein, fb19c03 Protein, wu:fb17e03 Protein, wu:fb18c06 Protein, wu:fb19c03 Protein, zgc:85979 Protein, zgc:92452 Protein, poly(A) binding protein nuclear 1 Protein, poly(A) binding protein, nuclear 1 Protein, poly(A) binding protein 2 Protein, poly(A) binding protein, nuclear 1 S homeolog Protein, poly(A) binding protein, nuclear 1 L homeolog Protein, polyadenylate-binding protein 2 Protein, poly(A) binding protein Pab2 Protein, PABPN1 Protein, Pabpn1 Protein, PAB2 Protein, pabpn1.S Protein, pabpn1.L Protein, LOC100728725 Protein, pab2 Protein, pabpn1 Protein

Hintergrund: PABPN1 is an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene. Recombinant human PABPN1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 23.8 kDa (211aa)

NCBI Accession: NP_004634

UniProt: Q86U42