Norrie Disease (Pseudoglioma) Protein (NDP) (AA 25-133) (His tag)

Produktnummer ABIN5853193

Produktdetails

Target: Norrie Disease (Pseudoglioma) (NDP)

Protein-Typ: Recombinant

Proteineigenschaft: AA 25-133

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Norrie Disease (Pseudoglioma) Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSKTDSSFI MDSDPRRCMR HHYVDSISHP LYKCSSKMVL LARCEGHCSQ ASRSEPLVSF STVLKQPFRS SCHCCRPQTS KLKALRLRCS GGMRLTATYR YILSCHCEEC NS

Reinheit: > 80 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Denatured

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M urea, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: Norrie Disease (Pseudoglioma) (NDP)

Andere Bezeichnung: NDP (NDP Produkte)

Synonyme: EVR2 Protein, FEVR Protein, ND Protein, evr2 Protein, fevr Protein, xnorrin Protein, Ndph Protein, RGD1563968 Protein, NDP, norrin cystine knot growth factor Protein, Norrie disease (pseudoglioma) L homeolog Protein, Norrie disease (pseudoglioma) (human) Protein, NDP Protein, ndp.L Protein, Ndp Protein

Hintergrund: Norrin precursor, also known as NDP, is a secreted regulatory protein. It activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. This protein plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. It may be involved in a pathway that regulates neural cell differentiation and proliferation. Recombinant human NDP protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 14.8 kDa (132aa)

NCBI Accession: NP_000257

UniProt: Q00604

Pathways: Sensory Perception of Sound