UFD1L Protein (AA 1-307) (His tag)

Produktnummer ABIN5853130

Produktdetails

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-307

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses UFD1L Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSMFSFNMF DHPIPRVFQN RFSTQYRCFS VSMLAGPNDR SDVEKGGKII MPPSALDQLS RLNITYPMLF KLTNKNSDRM THCGVLEFVA DEGICYLPHW MMQNLLLEEG GLVQVESVNL QVATYSKFQP QSPDFLDITN PKAVLENALR NFACLTTGDV IAINYNEKIY ELRVMETKPD KAVSIIECDM NVDFDAPLGY KEPERQVQHE ESTEGEADHS GYAGELGFRA FSGSGNRLDG KKKGVEPSPS PIKPGDIKRG IPNYEFKLGK ITFIRNSRPL VKKVEEDEAG GRFVAFSGEG QSLRKKGRKP

Reinheit: > 85 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.1M NaCl, 30 % glycerol, 1  mM DTT

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: UFD1L (Ubiquitin Fusion Degradation Protein 1 Homolog (UFD1L))

Andere Bezeichnung: uFD1L (UFD1L Produkte)

Synonyme: UFD1 Protein, Ufd1 Protein, ufd1 Protein, wu:fc55f04 Protein, zgc:92341 Protein, Ufd1l Protein, ubiquitin recognition factor in ER associated degradation 1 Protein, ubiquitin recognition factor in ER-associated degradation 1 Protein, ubiquitin fusion degradation 1 like (yeast) Protein, ubiquitin recognition factor in ER associated degradation 1 S homeolog Protein, ubiquitin fusion degradation protein 1 homolog Protein, Ubiquitin Fusion Degradation (yeast UFD homolog) Protein, UFD1 Protein, Ufd1 Protein, UFD1L Protein, ufd1.S Protein, ufd1l Protein, ufd1 Protein, EHI_125920 Protein, LOC100166745 Protein, LOC100635687 Protein, LOC100648660 Protein, ufd-1 Protein

Hintergrund: UFD1L forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. Recombinant human uFD1L protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Molekulargewicht: 36.9 kDa (330aa), confirmed by MALDI-TOF (Molecular size on SDS-PAGE will appear higher)

NCBI Accession: NP_005650

UniProt: Q92890