RCHY1 Protein (AA 1-261) (His tag)

Produktnummer ABIN5853062

Produktdetails

Target: RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-261

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses RCHY1 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MGSSHHHHHH SSGLVPRGSH MGSMAATARE DGASGQERGQ RGCEHYDRGC LLKAPCCDKL YTCRLCHDNN EDHQLDRFKV KEVQCINCEK IQHAQQTCEE CSTLFGEYYC DICHLFDKDK KQYHCENCGI CRIGPKEDFF HCLKCNLCLA MNLQGRHKCI ENVSRQNCPI CLEDIHTSRV VAHVLPCGHL LHRTCYEEML KEGYRCPLCM HSALDMTRYW RQLDDEVAQT PMPSEYQNMT VDILCNDCNG RSTVQFHILG MKCKICESYN TAQAGGRRIS LDQQ

Reinheit: > 85 % by SDS - PAGE

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Denatured

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M uREA, 10 % glycerol

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: RCHY1 (Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))

Andere Bezeichnung: RCHY1 (RCHY1 Produkte)

Synonyme: ARNIP Protein, CHIMP Protein, PIRH2 Protein, PRO1996 Protein, RNF199 Protein, ZNF363 Protein, Pirh2 Protein, Zfp363 Protein, Znf363 Protein, wu:fb37e07 Protein, zgc:101128 Protein, RCHY1 Protein, arnip Protein, chimp Protein, pirh2 Protein, harnip Protein, rnf199 Protein, znf363 Protein, pro1996 Protein, ring finger and CHY zinc finger domain containing 1 Protein, ring finger and CHY zinc finger domain containing 1 L homeolog Protein, RCHY1 Protein, Rchy1 Protein, rchy1 Protein, rchy1.L Protein

Hintergrund: RCHY1 has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Recombinant human RCHY1 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molekulargewicht: 32.5 kDa (284aa)

NCBI Accession: NP_056251

UniProt: Q96PM5