PITX3 Protein (AA 1-302, full length) (His tag)
-
- Target Alle PITX3 Proteine anzeigen
- PITX3 (Pituitary Homeobox 3 (PITX3))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- AA 1-302, full length
-
Spezies
- Maus
-
Quelle
- Hefe
- Aufreinigungstag / Konjugat
- Dieses PITX3 Protein ist gelabelt mit His tag.
- Applikation
- SDS-PAGE (SDS)
- Sequenz
- MEFGLLGEAE ARSPALSLSD AGTPHPPLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERSQQAELCK GGFAAPLGGL VPPYEEVYPG YSYGNWPPKA LAPPLAAKTF PFAFNSVNVG PLASQPVFSP PSSIAASMVP SAAAAPGTVP GPGALQGLGG APPGLAPAAV SSGAVSCPYA SAAAAAAAAA SSPYVYRDPC NSSLASLRLK AKQHASFSYP AVPGPPPAAN LSPCQYAVER PV
- Aufreinigung
- SDS-PAGE
- Reinheit
- > 90 %
- Top Product
- Discover our top product PITX3 Protein
-
-
- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Lagerung
- -80 °C,4 °C,-20 °C
- Informationen zur Lagerung
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- Target
- PITX3 (Pituitary Homeobox 3 (PITX3))
- Andere Bezeichnung
- PITX3 (PITX3 Produkte)
- Synonyme
- CTPP4 Protein, CTRCT11 Protein, PTX3 Protein, pitx3 Protein, Ptx3 Protein, ak Protein, zgc:109716 Protein, pitx3-A Protein, xPitx3 Protein, paired like homeodomain 3 Protein, paired-like homeodomain 3 Protein, paired like homeodomain 3 L homeolog Protein, paired-like homeodomain transcription factor 3 Protein, paired-like homeodomain transcription factor Pitx3 Protein, PITX3 Protein, Pitx3 Protein, pitx3.L Protein, pitx3 Protein
- Hintergrund
- Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the tporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle.
- Molekulargewicht
- 33.7 kDa
- UniProt
- O35160
-