CHMP2A
Spezies: Human
Wirt: Tobacco (Nicotiana tabacum)
Recombinant
>80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ELISA, SDS, WB
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.1-2 mg/mL
Buffer
20 mM Tris-HCl based buffer, pH 8.0
Lagerung
-80 °C,4 °C,-20 °C
Informationen zur Lagerung
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target
CHMP2A
(Charged Multivesicular Body Protein 2A (CHMP2A))
BC-2 Protein, BC2 Protein, CHMP2 Protein, VPS2 Protein, VPS2A Protein, 1500016L11Rik Protein, RGD1305050 Protein, bc-2 Protein, bc2 Protein, chmp2 Protein, vps2 Protein, vps2a Protein, fj10d05 Protein, wu:fi18h03 Protein, wu:fj10d05 Protein, zgc:55361 Protein, charged multivesicular body protein 2a Protein, charged multivesicular body protein 2A Protein, Charged multivesicular body protein 2a Protein, charged multivesicular body protein 2A L homeolog Protein, ATEG_06167 Protein, LOC5570080 Protein, EDI_289610 Protein, PTRG_09933 Protein, NAEGRDRAFT_39042 Protein, PITG_17335 Protein, Tsp_00033 Protein, LOC100284170 Protein, LOC100284688 Protein, chm2a Protein, chmp2a Protein, CHMP2A Protein, Chmp2a Protein, chmp2a.L Protein
Hintergrund
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting mbrane of the endosome and mostly are delivered to lysosomes enabling degradation of mbrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating mbrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent mbrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or mbrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.