HNRNPK Protein (AA 3-459, partial) (GST tag)

Produktnummer ABIN4976357

Produktdetails

Target: HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

Protein-Typ: Recombinant

Proteineigenschaft: AA 3-459, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HNRNPK Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: TEQPEETFPN TETNGEFGKR PAEDMEEEQA FKRSRNTDEM VELRILLQSK NAGAVIGKGG KNIKALRTDY NASVSVPDSS GPERILSISA DIETIGEILK KIIPTLEEGL QLPSPTATSQ LPLESDAVEC LNYQHYKGSD FDCELRLLIH QSLAGGIIGV KGAKIKELRE NTQTTIKLFQ ECCPHSTDRV VLIGGKPDRV VECIKIILDL ISESPIKGRA QPYDPNFYDE TYDYGGFTMM FDDRRGRPVG FPMRGRGGFD RMPPGRGGRP MPPSRRDYDD MSPRRGPPPP PPGRGGRGGS RARNLPLPPP PPPRGGDLMA YDRRGRPGDR YDGMVGFSAD ETWDSAIDTW SPSEWQMAYE PQGGSGYDYS YAGGRGSYGD LGGPIITTQV TIPKDLAGSI IGKGGQRIKQ IRHESGASIK IDEPLEGSED RIITITGTQD QIQNAQYLLQ NSVKQYADVE GF

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

Andere Bezeichnung: HNRPK (HNRNPK Produkte)

Synonyme: CSBP Protein, HNRPK Protein, TUNP Protein, Csbp Protein, Hnrpk Protein, hnrpk Protein, MGC75642 Protein, wu:fb37h02 Protein, wu:fi34c04 Protein, zgc:66162 Protein, KBBP Protein, NOVA Protein, heterogeneous nuclear ribonucleoprotein K Protein, heterogeneous nuclear ribonucleoprotein K S homeolog Protein, heterogeneous nuclear ribonucleoprotein k Protein, HNRNPK Protein, Hnrnpk Protein, hnrnpk.S Protein, hnrnpk Protein, LOC5565718 Protein, CpipJ_CPIJ000130 Protein, NGK_p0004 Protein

Hintergrund: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction . As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.3 Publications

Molekulargewicht: 78.1 kDa

UniProt: P61978