PSMA7 Protein (AA 44-275, partial) (GST tag)

Produktnummer ABIN5712137

Produktdetails

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Protein-Typ: Recombinant

Proteineigenschaft: AA 44-275, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses PSMA7 Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: TTIAGVVYKD GIVLGADTRA TEGMVVADKN CSKIHFISPN IYCCGAGTAA DTDMTTQLIS SNLELHSLST GRLPRVVTAN RMLKQMLFRY QGYIGAALVL GGVDVTGPHL YSIYPHGSTD KLPYVTMGSG SLAAMAVFED KFRPDMEEEE AKNLVSEAIA AGIFNDLGSG SNIDLCVISK NKLDFLRPYT VPNKKGTRLG RYRCEKGTTA VLTEKITPLE IEVLEETVQT MD

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Andere Bezeichnung: PSA7 (PSMA7 Produkte)

Synonyme: C6 Protein, HSPC Protein, RC6-1 Protein, XAPC7 Protein, C6-I Protein, DDBDRAFT_0185059 Protein, DDBDRAFT_0217080 Protein, DDB_0185059 Protein, DDB_0217080 Protein, hspc Protein, rc6-1 Protein, xapc7 Protein, psma7 Protein, psma4-B Protein, proteasome subunit alpha 7 Protein, proteasome (prosome, macropain) subunit, alpha type 7 Protein, 20S proteasome subunit alpha-7 Protein, proteasome subunit alpha 7 S homeolog Protein, proteasome subunit alpha 7 L homeolog Protein, PSMA7 Protein, Psma7 Protein, psmA7 Protein, psma7 Protein, psma7.S Protein, psma7.L Protein

Hintergrund: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with AP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response.

Molekulargewicht: 52.5 kDa

UniProt: O14818

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA