GEMIN7 Protein (AA 1-131, full length) (GST tag)

Produktnummer ABIN5711759

Produktdetails

Target: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Protein-Typ: Recombinant

Proteineigenschaft: full length, AA 1-131

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses GEMIN7 Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MQTPVNIPVP VLRLPRGPDG FSRGFAPDGR RAPLRPEVPE IQECPIAQES LESQEQRARA ALRERYLRSL LAMVGHQVSF TLHEGVRVAA HFGATDLDVA NFYVSQLQTP IGVQAEALLR CSDIISYTFK P

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: GEMIN7 (Gem (Nuclear Organelle) Associated Protein 7 (GEMIN7))

Andere Bezeichnung: GEMI7 (GEMIN7 Produkte)

Synonyme: SIP3 Protein, GEMIN7 Protein, Gemin7 Protein, 2400008I04Rik Protein, AI120175 Protein, AI461688 Protein, gem nuclear organelle associated protein 7 Protein, gem (nuclear organelle) associated protein 7 Protein, GEMIN7 Protein, Gemin7 Protein

Hintergrund: The SMN complex plays a catalyst role in the assbly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assbly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assbly of core snRNPs and their transport to the nucleus.

Molekulargewicht: 41.9 kDa

UniProt: Q9H840

Pathways: Ribonucleoprotein Complex Subunit Organization