CPEB1
Spezies: Human
Wirt: Tobacco (Nicotiana tabacum)
Recombinant
>80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
SDS, WB, ELISA
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
0.1-2 mg/mL
Buffer
20 mM Tris-HCl based buffer, pH 8.0
Lagerung
-80 °C,4 °C,-20 °C
Informationen zur Lagerung
Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target
CPEB1
(Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))
CEBP Protein, CPE-BP1 Protein, CPEB Protein, AU024112 Protein, Cpeb Protein, mCPEB Protein, CPEB1 Protein, cpeb1 Protein, ZOR-1 Protein, cepb1b Protein, fd15c06 Protein, wu:fd15c06 Protein, zorba Protein, cytoplasmic polyadenylation element binding protein 1 Protein, hypothetical protein Protein, cytoplasmic polyadenylation element binding protein 1 L homeolog Protein, cytoplasmic polyadenylation element binding protein 1b Protein, cytoplasmic polyadenylation element binding protein 1 S homeolog Protein, CPEB1 Protein, Cpeb1 Protein, cpeb1 Protein, LOAG_17395 Protein, cpeb1.L Protein, cpeb1b Protein, cpeb1.S Protein
Hintergrund
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation elent (CPE), an uridine-rich sequence elent (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation . Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses . Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation . Induces the assbly of stress granules in the absence of stress.