HSD17B10 Protein (AA 2-261) (His-SUMO Tag)

Produktnummer ABIN5711745

Produktdetails

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-261

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HSD17B10 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: AAACRSVKGL VAVITGGASG LGLATAERLV GQGASAVLLD LPNSGGEAQA KKLGNNCVFA PADVTSEKDV QTALALAKGK FGRVDVAVNC AGIAVASKTY NLKKGQTHTL EDFQRVLDVN LMGTFNVIRL VAGEMGQNEP DQGGQRGVII NTASVAAFEG QVGQAAYSAS KGGIVGMTLP IARDLAPIGI RVMTIAPGLF GTPLLTSLPE KVCNFLASQV PFPSRLGDPA EYAHLVQAII ENPFLNGEVI RLDGAIRMQP

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Andere Bezeichnung: HCD2 (HSD17B10 Produkte)

Synonyme: hadh2 Protein, im:6899159 Protein, wu:fj61f03 Protein, zgc:101605 Protein, abad Protein, camr Protein, erab Protein, hcd2 Protein, hsd10 Protein, mhbd Protein, mrpp2 Protein, mrx17 Protein, mrx31 Protein, mrxs10 Protein, schad Protein, sdr5c1 Protein, HADH2 Protein, HSD17B10 Protein, 17b-HSD10 Protein, ABAD Protein, CAMR Protein, DUPXp11.22 Protein, ERAB Protein, HCD2 Protein, MHBD Protein, MRPP2 Protein, MRX17 Protein, MRX31 Protein, MRXS10 Protein, SCHAD Protein, SDR5C1 Protein, 17bHSD10 Protein, Ads9 Protein, Hadh2 Protein, hydroxysteroid (17-beta) dehydrogenase 10 Protein, hydroxysteroid 17-beta dehydrogenase 10 Protein, hydroxysteroid (17-beta) dehydrogenase 10 L homeolog Protein, HSD17B10 Protein, hsd17b10 Protein, hsd17b10.L Protein, Hsd17b10 Protein

Hintergrund: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Molekulargewicht: 42.8 kDa

UniProt: Q99714