WDR77 Protein (AA 1-312, partial) (His-SUMO Tag)

Produktnummer ABIN5711731

Produktdetails

Target: WDR77 (WD Repeat Domain 77 (WDR77))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-312, partial

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses WDR77 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MRKETPPPLV PPAAREWNLP PNAPACMERQ LEAARYRSDG ALLLGASSLS GRCWAGSLWL FKDPCAAPNE GFCSAGVQTE AGVADLTWVG ERGILVASDS GAVELWELDE NETLIVSKFC KYEHDDIVST VSVLSSGTQA VSGSKDICIK VWDLAQQVVL SSYRAHAAQV TCVAASPHKD SVFLSCSEDN RILLWDTRCP KPASQIGCSA PGYLPTSLAW HPQQSEVFVF GDENGTVSLV DTKSTSCVLS SAVHSQCVTG LVFSPHSVPF LASLSEDCSL AVLDSSLSEL FRSQAHRDFV RDATWSPLNH SL

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: WDR77 (WD Repeat Domain 77 (WDR77))

Andere Bezeichnung: MEP50 (WDR77 Produkte)

Synonyme: MEP-50 Protein, MEP50 Protein, Nbla10071 Protein, RP11-552M11.3 Protein, p44 Protein, p44/Mep50 Protein, 2610003I18Rik Protein, 2610312E17Rik Protein, C79984 Protein, p44/MEP50 Protein, RGD1310479 Protein, mep50 Protein, valois Protein, WDR77 Protein, zgc:65780 Protein, zgc:77274 Protein, WD repeat domain 77 Protein, WD repeat domain 77 S homeolog Protein, WDR77 Protein, Wdr77 Protein, wdr77.S Protein, wdr77 Protein

Hintergrund: Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assbly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.

Molekulargewicht: 49.5 kDa

UniProt: Q9BQA1

Pathways: Ribonucleoprotein Complex Subunit Organization