IFNK Protein (AA 24-195) (His tag)

Produktnummer ABIN5710800

Produktdetails

Target: IFNK (Interferon, kappa (IFNK))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-195

Spezies: Rind (Kuh)

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses IFNK Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Sequenz: CYLSEDHMLG ARENLRLLAR MNRLSPHPCL QDRKDFGLPQ EMVEGNQLQK DQAISVLHEM LQQCFNLFYT EHSSAAWNTT LLEQLCTGLQ QQLEDLDACL GPVMGEKDSD MGRMGPILTV KKYFQGIHVY LKEKEYSDCA WEIIRVEMMR ALSSSTTLQK RLRKMGGDLN SL

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: IFNK (Interferon, kappa (IFNK))

Andere Bezeichnung: IFNT1 (IFNK Produkte)

Synonyme: IFNK Protein, IFNT1 Protein, INFE1 Protein, RP11-27J8.1 Protein, interferon kappa Protein, IFNK Protein, Ifnk Protein

Hintergrund: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.

Molekulargewicht: 23.8 kDa

UniProt: P15696