KCNAB2 Protein (AA 1-367, full length) (His-SUMO Tag)

Produktnummer ABIN5709787

Produktdetails

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-367, full length

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses KCNAB2 Protein ist gelabelt mit His-SUMO Tag.

Applikation: SDS-PAGE (SDS)

Sequenz: MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE IDSILGNKPY SKKDYRS

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Andere Bezeichnung: KCAB2 (KCNAB2 Produkte)

Synonyme: kcnab2 Protein, KCNAB2 Protein, DKFZp459E056 Protein, akr6a5 Protein, kcna2b Protein, kvb-a Protein, kvb2 Protein, kvbeta2 Protein, kvbeta2.1 Protein, kvbeta2.2 Protein, AKR6A5 Protein, HKvbeta2 Protein, HKvbeta2.1 Protein, HKvbeta2.2 Protein, KCNA2B Protein, KV-BETA-2 Protein, Kvbeta2.1 Protein, F5 Protein, I2rf5 Protein, Kcnb3 Protein, kv-beta-2 Protein, potassium channel, voltage gated subfamily A regulatory beta subunit 1 Protein, potassium voltage-gated channel subfamily A regulatory beta subunit 2 Protein, potassium voltage-gated channel, shaker-related subfamily, beta member 2 a Protein, potassium channel, voltage gated subfamily A regulatory beta subunit 2 L homeolog Protein, voltage-gated potassium channel subunit beta-2 Protein, potassium voltage-gated channel, shaker-related subfamily, beta member 2 Protein, kcnab1 Protein, KCNAB2 Protein, kcnab2a Protein, kcnab2.L Protein, LOC397248 Protein, Kcnab2 Protein

Hintergrund: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell mbrane, and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore . Promotes KCNA4 channel closure . Modulates the functional properties of KCNA5 . Enhances KCNB2 channel activity . Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) .

Molekulargewicht: 56.97 kDa

UniProt: Q13303