CRHR1 Protein (AA 24-121) (GST tag)

Produktnummer ABIN5709325

Produktdetails

Target: CRHR1 (Corticotropin Releasing Hormone Receptor 1 (CRHR1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-121

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CRHR1 Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Sequenz: SLQDQHCESL SLASNISGLQ CNASVDLIGT CWPRSPAGQL VVRPCPAFFY GVRYNTTNNG YRECLANGSW AARVNYSECQ EILNEEKKSK VHYHVAVI

Aufreinigung: SDS-PAGE

Reinheit: > 90 %

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Lagerung: -80 °C,4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Antigendetails

Target: CRHR1 (Corticotropin Releasing Hormone Receptor 1 (CRHR1))

Andere Bezeichnung: CRFR1 (CRHR1 Produkte)

Synonyme: CRF-R Protein, CRF-R-1 Protein, CRF-R1 Protein, CRF1 Protein, CRFR-1 Protein, CRFR1 Protein, CRH-R-1 Protein, CRH-R1 Protein, CRH-R1h Protein, CRHR Protein, CRHR1L Protein, CRHR1f Protein, Crhr Protein, crhr1 Protein, crhr1-A Protein, CRHR1 Protein, CRHR1-IT1-CRHR1 Protein, MGC57346-CRHR1 Protein, corticotropin releasing hormone receptor 1 Protein, corticotropin releasing hormone receptor 1, gene 2 S homeolog Protein, corticotropin-releasing factor receptor 1 Protein, LINC02210-CRHR1 readthrough Protein, CRHR1 Protein, Crhr1 Protein, crhr1.2.S Protein, LOC610380 Protein, LOC100065598 Protein, LINC02210-CRHR1 Protein, crhr1 Protein

Hintergrund: G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal bryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

Molekulargewicht: 38.3 kDa

UniProt: P34998

Pathways: Hormone Transport, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Feeding Behaviour, Negative Regulation of Transporter Activity