Synuclein, alpha (SNCA) (full length) Protein

Details zu Produkt Nr. ABIN5065826, Anbieter: Anmelden zum Anzeigen
Proteinname
  • snca
  • MGC64356
  • LOC619283
  • NACP
  • alphaSYN
  • PARK1
  • PARK4
  • PD1
  • synuclein alpha L homeolog
  • alpha-synuclein
  • synuclein alpha
  • synuclein, alpha
  • snca.L
  • LOC619283
  • SNCA
  • Snca
Proteineigenschaft
full length
30
25
2
2
1
1
1
1
1
1
1
1
1
Spezies
Human
47
20
4
1
1
1
1
1
1
1
1
1
1
1
Quelle
Escherichia coli (E. coli)
54
12
4
2
1
Protein-Typ
Recombinant
Applikation
In vitro Assay (in vitro), In vivo Studies (in vivo), SDS-PAGE (SDS), Western Blotting (WB)
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Sequenz MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Reinigung Ion-exchange Purified
Reinheit 92% pure using SDS-PAGE analysis.
Proteinname
Hintergrund Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Molekulargewicht 14.46 kDa
Gen-ID 6622
NCBI Accession NP_000336
UniProt P37840
Pathways Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity
Kommentare

Certified 92% pure using SDS-PAGE analysis.

Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration Lot specific
Buffer 0.2μm filtered solution in 20 mM tris, 150 mM NaCl pH 7.5
Lagerung -80 °C
Bilder des Herstellers
SDS-PAGE (SDS) image for Synuclein, alpha (SNCA) (full length) protein (ABIN5065826) SDS-PAGE of ~14 kDa Human Recombinant Alpha Synuclein Protein Aggregate (Control) . L...
Immunofluorescence (fixed cells) (IF/ICC) image for Synuclein, alpha (SNCA) (full length) protein (ABIN5065826) Primary rat hippocampal neurons show lewy body inclusion formation when treated with ...
 image for Synuclein, alpha (SNCA) (full length) protein (ABIN5065826) Active alpha synuclein aggregate seeds the formation of new alpha Synuclein aggregat...