IL23R Protein (AA 24-372) (Fc Tag)

Produktnummer ABIN4949177

Produktdetails

Target: IL23R (Interleukin 23 Receptor (IL23R))

Protein-Typ: Recombinant

Proteineigenschaft: AA 24-372

Spezies: Maus

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL23R Protein ist gelabelt mit Fc Tag.

Applikation: Functional Studies (Func)

Sequenz: AA 24-372

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 66.8 kDa. As a result of glycosylation, the protein migrates as 90-100 kDa under reducing (R) condition, and 180-200 kDa under non-reducing (NR) condition (SDS-PAGE).

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Tris with Glycine, Arginine and NaCl,  pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Antigendetails

Target: IL23R (Interleukin 23 Receptor (IL23R))

Andere Bezeichnung: IL-23R (IL23R Produkte)

Synonyme: IL-23R Protein, IL23R Protein, il-23r Protein, interleukin 23 receptor Protein, IL23R Protein, il23r Protein, Il23r Protein

Hintergrund: Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner. Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Molekulargewicht: 66.8 kDa

NCBI Accession: NP_653131

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation