ELAVL4 Protein (His tag)

Produktnummer ABIN3200994

Produktdetails

Target: ELAVL4 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) (ELAVL4))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses ELAVL4 Protein ist gelabelt mit His tag.

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: Expressed  in E.Coli and purified by affinity chromatography 

Reinheit: > 95%

Endotoxin-Niveau: less than 0.1 ng/µg (1 IEU/µg)

Anwendungsinformationen

Applikationshinweise: Detection of  anti-Hu  paraneoplastic antibodies via WB or ELISA assay. Identification of  regulatory elements in mRNA. 

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Storage buffer PBS, pH 7.2

Lagerung: -20 °C

Informationen zur Lagerung: Heat stable , shipped at ambient temp.  Upon delivery aliquot and store in fridge , longterm storage at  -20°C.

Referenzen

Chung, Jiang, Cheng, Furneaux: "Purification and properties of HuD, a neuronal RNA-binding protein." in: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11518-24, (1996) (PubMed).

Antigendetails

Target: ELAVL4 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 4 (Hu Antigen D) (ELAVL4))

Andere Bezeichnung: ELAV-like protein 4 (ELAVL4 Produkte)

Synonyme: HUD Protein, PNEM Protein, HuD Protein, RGD1561943 Protein, r-HuD Protein, elrd Protein, hud Protein, wu:fc24h01 Protein, Elav Protein, Hud Protein, elrD Protein, elrD1 Protein, elrD2 Protein, ELAV-like protein 4 Protein, ELAV like RNA binding protein 4 Protein, ELAV like neuron-specific RNA binding protein 4 Protein, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) Protein, ELAV like neuron-specific RNA binding protein 4 L homeolog Protein, LOC100282339 Protein, LOC100284149 Protein, ELAVL4 Protein, Elavl4 Protein, elavl4 Protein, elavl4.L Protein

Hintergrund: HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.
The HuD/ELAVL4 protein is an RNA-binding protein.
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.
HuD was originaly discovered as the paraneoplastic antigen expressed in neuroendocrine tumors. Recombinant HuD was first used to assay the presence of anti-Hu antibodies and thereby diagnose the presence of small cell lung cancer and subacute sensory neuronopathy. In normal cells , it functions to regulate gene expression and the recombinant protein has been used to identify regualtory elements in mRNA.

Molekulargewicht: 66 kDa