FKBP1A Protein (AA 1-108) (His tag)

Produktnummer ABIN2870639

Produktdetails

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-108

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses FKBP1A Protein ist gelabelt mit His tag.

Sequenz: AA 1-108

Produktmerkmale: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).

Reinheit: >95 % as determined by SDS-PAGE.

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM HEPES, 150 mM NaCl, pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Antigendetails

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Andere Bezeichnung: FKBP12 (FKBP1A Produkte)

Synonyme: 12kDa Protein, FKBP12 Protein, FKBP12-T1 Protein, FKBP12-T2 Protein, Fkbp Protein, Fkbp1 Protein, mFKBP1 Protein, mFKBP12 Protein, FKBP-12 Protein, FKBP-1A Protein, FKBP1 Protein, Rotamase Protein, Fkbp12 Protein, ARABIDOPSIS THALIANA FK506-BINDING PROTEIN 12 Protein, ATFKBP12 Protein, FK506-binding protein 12 Protein, IMMUNOPHILIN Protein, MSJ1.19 Protein, MSJ1_19 Protein, PKC12 Protein, PKCI2 Protein, PPIASE Protein, FKBP1B Protein, Fkbp2 Protein, fj02g10 Protein, zgc:73373 Protein, wu:fj02g10 Protein, FKBP1A Protein, Bmfkbp13 Protein, zgc:103752 Protein, FK506 binding protein 1a Protein, FK506 binding protein 1A Protein, FK506-binding protein Protein, FK506-binding protein 12 Protein, FK506 binding protein 1Aa Protein, FK506 binding protein 1C Protein, FK506-binding protein 59 Protein, FK506 binding protein like Protein, FK506 binding protein 1A L homeolog Protein, FK506 binding protein 1Ab Protein, Fkbp1a Protein, FKBP1A Protein, Fkbp12 Protein, FKBP12 Protein, fkbp1aa Protein, FKBP1C Protein, EHI_180160 Protein, LOC5573443 Protein, Fkbp13 Protein, FKBPL Protein, fkbp1a.L Protein, fkbp1ab Protein

Hintergrund: Peptidyl-prolyl cis-trans isomerase FKBP1A, a member of the FKBP-type PPIase family and FKBP1 subfamily, is also known as FK506-binding protein 1A, immunophilin FKBP12 and 12 kDa FK506-binding protein, which contains one PPIase FKBP-type domain. FKBP1A is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 (tacrolimus) and rapamycin (sirolimus).FKBP1A interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. FKBP1A can also interact with multiple intracellular calcium release channels including the tetrameric skeletal muscle ryanodine receptor. Furthermore, FKBP1A can recruite SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal.

Molekulargewicht: 12.8 kDa

NCBI Accession: NP_000792

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process