FBXW7 Protein (AA 1-553) (GST tag)

Produktnummer ABIN1990130

Produktdetails

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-553

Spezies: Human

Quelle: Wheat germ

Aufreinigungstag / Konjugat: Dieses FBXW7 Protein ist gelabelt mit GST tag.

Applikation: ELISA, Western Blotting (WB), Antibody Array (AA), Affinity Purification (AP)

Verwendungszweck: FBXW7 (Human) Recombinant Protein (P01)

Sequenz: MGFYGTLKMI FYKMKRKLDH GSEVRSFSLG KKPCKVSEYT STTGLVPCSA TPTTFGDLRA ANGQGQQRRR ITSVQPPTGL QEWLKMFQSW SGPEKLLALD ELIDSCEPTQ VKHMMQVIEP QFQRDFISLL PKELALYVLS FLEPKDLLQA AQTCRYWRIL AEDNLLWREK CKEEGIDEPL HIKRRKVIKP GFIHSPWKSA YIRQHRIDTN WRRGELKSPK VLKGHDDHVI TCLQFCGNRI VSGSDDNTLK VWSAVTGKCL RTLVGHTGGV WSSQMRDNII ISGSTDRTLK VWNAETGECI HTLYGHTSTV RCMHLHEKRV VSGSRDATLR VWDIETGQCL HVLMGHVAAV RCVQYDGRRV VSGAYDFMVK VWDPETETCL HTLQGHTNRV YSLQFDGIHV VSGSLDTSIR VWDVETGNCI HTLTGHQSLT SGMELKDNIL VSGNADSTVK IWDIKTGQCL QTLQGPNKHQ SAVTCLQFNK NFVITSSDDG TVKLWDLKTG EFIRNLVTLE SGGSGGVVWR IRASNTKLVC AVGSRNGTEE TKLLVLDFDV DMK

Produktmerkmale: Human FBXW7 full-length ORF (BAA91986.1, 1 a.a. - 553 a.a.) recombinant protein with GST tag at N-terminal.

Aufreinigung: in vitro wheat germ expression system

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.

Handhabung: Aliquot to avoid repeated freezing and thawing.

Lagerung: -80 °C

Informationen zur Lagerung: Best use within three months from the date of receipt of this protein.

Antigendetails

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Andere Bezeichnung: FBXW7 (FBXW7 Produkte)

Synonyme: cdc4 Protein, AGO Protein, CDC4 Protein, FBW6 Protein, FBW7 Protein, FBX30 Protein, FBXO30 Protein, FBXW6 Protein, SEL-10 Protein, SEL10 Protein, hAgo Protein, hCdc4 Protein, 1110001A17Rik Protein, Cdc4 Protein, Fbw7 Protein, Fbwd6 Protein, Fbx30 Protein, Fbxo30 Protein, Fbxw6 Protein, F-box and WD repeat domain containing 7 Protein, F-box and WD-40 domain protein 7 Protein, Fbxw7 Protein, FBXW7 Protein, fbxw7 Protein

Hintergrund: Synonyms: AGO,CDC4,DKFZp686F23254,FBW6,FBW7,FBX30,FBXO30,FBXW6,FLJ16457,SEL-10,SEL10
Gene Description: F-box and WD repeat domain containing 7
Gene Name: FBXW7
Gene Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class, in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Three transcript variants encoding three different isoforms have been found for this gene.
GenBank: AK001933.1, BAA91986.1

Molekulargewicht: 88.7 kDa (theoreatical)

Gen-ID: 55294

Pathways: Notch Signalweg, EGFR Signaling Pathway