KAT5 Protein (His tag)

Produktnummer ABIN2745869

Produktdetails

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Insect cells (Sf21)

Aufreinigungstag / Konjugat: Dieses KAT5 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS)

Kreuzreaktivität: Human

Produktmerkmale: Human TIP60 is fused to a His-tag.

Reinheit: >95 % (SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

100-200ng are required for standard HAT assay.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In 50 mM TRIS-HCl, pH 7.5, containing 100 mM sodium chloride, 0.2 % NP-40, 50 mM imidazole and 10 % glycerol.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Short Term Storage: -20°C
Long Term Storage: -80°C
Stable for at least 6 months after receipt when stored at -80°C.

Haltbarkeit: 6 months

Antigendetails

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Andere Bezeichnung: TIP60 (KAT5 Produkte)

Synonyme: 6121 Protein, CG6121 Protein, DmEG0007.7 Protein, Dmel/TIP60 Protein, Dmel\\CG6121 Protein, Dmel\\TIP60 Protein, EG0007.7 Protein, EG:EG0007.7 Protein, TIP60 Protein, dTIP60 Protein, dTip60 Protein, dmHAG405 Protein, im:6908768 Protein, wu:fb55b08 Protein, zgc:110752 Protein, ESA1 Protein, HTATIP Protein, HTATIP1 Protein, PLIP Protein, TIP Protein, ZC2HC5 Protein, cPLA2 Protein, AI839539 Protein, CPLA2 Protein, Htatip Protein, Htatip1 Protein, Tip55 Protein, Tip60 Protein, K(lysine) acetyltransferase 5a Protein, lysine acetyltransferase 5 Protein, Tat interactive protein 60kDa Protein, histone acetyltransferase Tip60 Protein, tip60, putative Protein, K(lysine) acetyltransferase 5b Protein, K(lysine) acetyltransferase 5 Protein, kat5a Protein, KAT5 Protein, Tip60 Protein, LOC413101 Protein, LOC5579231 Protein, Smp_053140 Protein, kat5b Protein, Kat5 Protein

Hintergrund: TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway