4932434G09Rik Protein, POP1 homolog, ribonuclease P/MRP subunit Protein, processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae) Protein, POP1 Protein, Pop1 Protein
Hintergrund
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family (NLRs), including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). Pyrin domain-containing protein 1 (POP1) interacts with the protein Asc (Pycard) and modulates the interaction of Asc to NLR proteins.