C19ORF80 Protein (Fc Tag)

Produktnummer ABIN2745625

Produktdetails

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses C19ORF80 Protein ist gelabelt mit Fc Tag.

Applikation: SDS-PAGE (SDS)

Kreuzreaktivität: Human

Produktmerkmale: Human betatrophin (22-198) is fused at the C-terminus to the Fc portion of human IgG1.

Reinheit: >90 % (SDS-PAGE)

Endotoxin-Niveau: <0.1EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with 100 μL sterile water.

Konzentration: Lot specific

Buffer: Lyophilized. Contains PBS + 0.02 % CHAPS.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))

Andere Bezeichnung: Betatrophin (C19ORF80 Produkte)

Synonyme: ANGPTL8 Protein, PRO1185 Protein, PVPA599 Protein, RIFL Protein, TD26 Protein, angiopoietin like 8 Protein, ANGPTL8 Protein

Hintergrund: Betatrophin (RIFL, Lipasin, Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.

Molekulargewicht: ~50kDa

UniProt: Q6UXH0