SPRY2 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2732614

Produktdetails

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses SPRY2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Sprouty homolog 2 / SPRY2 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: SPRY2 (Sprouty Homolog 2 (SPRY2))

Andere Bezeichnung: Sprouty Homolog 2,spry2 (SPRY2 Produkte)

Synonyme: wu:fk66h11 Protein, wu:fk93e11 Protein, zgc:110440 Protein, hspry2 Protein, xspry2 Protein, sprouty2 Protein, Xsprouty2 Protein, sprouty-2 Protein, Xtsprouty2 Protein, hSPRY2 Protein, sprouty RTK signaling antagonist 2 Protein, sprouty RTK signaling antagonist 2 S homeolog Protein, sprouty homolog 2 (Drosophila) Protein, spry2 Protein, SPRY2 Protein, spry2.S Protein, Spry2 Protein

Hintergrund: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Molekulargewicht: 34.5 kDa

NCBI Accession: NP_005833

Pathways: EGFR Signaling Pathway, Sensory Perception of Sound, EGFR Downregulation