PML Protein (Transcript Variant 7) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2729210

Produktdetails

Target: PML (Promyelocytic Leukemia (PML))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 7

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses PML Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human PML / RNF71 (transcript variant 7) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: PML (Promyelocytic Leukemia (PML))

Andere Bezeichnung: Pml,rnf71 (PML Produkte)

Synonyme: MYL Protein, PP8675 Protein, RNF71 Protein, TRIM19 Protein, 1200009E24Rik Protein, AI661194 Protein, Trim19 Protein, RGD1562602 Protein, PML Protein, promyelocytic leukemia Protein, PML Protein, Pml Protein

Hintergrund: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molekulargewicht: 47.4 kDa

NCBI Accession: NP_150249

Pathways: p53 Signalweg, Retinoic Acid Receptor Signaling Pathway, Maintenance of Protein Location, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus