NR1I2 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2727546

Produktdetails

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 1

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NR1I2 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human NR1I2 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))

Andere Bezeichnung: Nr1i2 (NR1I2 Produkte)

Synonyme: BXR Protein, ONR1 Protein, PAR Protein, PAR1 Protein, PAR2 Protein, PARq Protein, PRR Protein, PXR Protein, SAR Protein, SXR Protein, PXR.1 Protein, PXR.2 Protein, PXR1 Protein, mPXR Protein, bxr Protein, nr1i2 Protein, onr1 Protein, xonr1 Protein, nuclear receptor subfamily 1 group I member 2 Protein, nuclear receptor subfamily 1, group I, member 2 Protein, nuclear receptor subfamily 1 group I member 2 S homeolog Protein, NR1I2 Protein, Nr1i2 Protein, nr1i2.S Protein, nr1i2 Protein

Hintergrund: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Molekulargewicht: 49.6 kDa

NCBI Accession: NP_003880

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway