NKX2-8 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2727355

Produktdetails

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses NKX2-8 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human NKX2-8 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: NKX2-8 (NK2 Homeobox 8 (NKX2-8))

Andere Bezeichnung: Nkx2-8 (NKX2-8 Produkte)

Synonyme: NKX2.8 Protein, NKX2H Protein, Nkx2-9 Protein, Nkx-2.9 Protein, Nkx2-8 Protein, Nkx2.9 Protein, tinman Protein, NK2 homeobox 8 Protein, NK2 homeobox 9 Protein, NKX2-8 Protein, Nkx2-9 Protein, Nkx2-8 Protein

Hintergrund: The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects.

Molekulargewicht: 25.7 kDa

NCBI Accession: NP_055175