ING3 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2723448

Produktdetails

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 1

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses ING3 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human ING3 (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: ING3 (Inhibitor of Growth Family, Member 3 (ING3))

Andere Bezeichnung: Ing3 (ING3 Produkte)

Synonyme: ING3 Protein, Eaf4 Protein, ING2 Protein, MEAF4 Protein, p47ING3 Protein, 1300013A07Rik Protein, P47ING3 Protein, zgc:56327 Protein, inhibitor of growth family member 3 Protein, inhibitor of growth family, member 3 Protein, inhibitor of growth protein 3 Protein, inhibitor of growth family member 3 L homeolog Protein, ING3 Protein, Ing3 Protein, CpipJ_CPIJ009396 Protein, ing3 Protein, ing3.L Protein

Hintergrund: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Molekulargewicht: 46.6 kDa

NCBI Accession: NP_061944