HGS Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2722699

Produktdetails

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses HGS Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human HGS / HRS protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Andere Bezeichnung: Hgs,hrs (HGS Produkte)

Synonyme: HRS Protein, Hrs Protein, fi34f05 Protein, zgc:63492 Protein, wu:fi34f05 Protein, Hgr Protein, ZFYVE8 Protein, CG2903 Protein, Dmel\\CG2903 Protein, HRS-2 Protein, Vps27 Protein, hrs Protein, l(2)23AB5 Protein, l(2)23Ad Protein, l(2)23Ad(Hrs) Protein, vps27 Protein, hgs Protein, hepatocyte growth factor-regulated tyrosine kinase substrate Protein, HGF-regulated tyrosine kinase substrate Protein, Hepatocyte growth factor regulated tyrosine kinase substrate Protein, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog Protein, HGS Protein, Hgs Protein, hgs Protein, Hrs Protein, hgs.L Protein

Hintergrund: Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation. [UniProtKB/Swiss-Prot Function]

Molekulargewicht: 86 kDa

NCBI Accession: NP_004703

Pathways: EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation