MVB12B Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2720746

Produktdetails

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 2

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses MVB12B Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human FAM125B (transcript variant 2) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: MVB12B (Multivesicular Body Subunit 12B (MVB12B))

Andere Bezeichnung: Fam125b (MVB12B Produkte)

Synonyme: C9orf28 Protein, FAM125B Protein, 2610200O14Rik Protein, 2610528K11Rik Protein, AI414895 Protein, Fam125b Protein, RGD1309709 Protein, fam125b Protein, mvb12b Protein, fam125ba Protein, zgc:152929 Protein, multivesicular body subunit 12B Protein, multivesicular body subunit 12B S homeolog Protein, multivesicular body subunit 12Ba Protein, MVB12B Protein, Mvb12b Protein, mvb12b.S Protein, mvb12ba Protein

Hintergrund: The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 24.3 kDa

NCBI Accession: NP_001011703