DYRK1A Protein (DYKDDDDK Tag)

Produktnummer ABIN2719885

Produktdetails

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Insect cells (Sf9)

Aufreinigungstag / Konjugat: Dieses DYRK1A Protein ist gelabelt mit DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human DYRK1A (full length, C-term DDK tag, transcript variant 1) protein expressed in Sf9 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 50 mM Tris-HCl, pH 8.0, 100 mM glycine, 10 % glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: DYRK1A (Dual-Specificity tyrosine-(Y)-phosphorylation Regulated Kinase 1A (DYRK1A))

Andere Bezeichnung: Dyrk1a (DYRK1A Produkte)

Synonyme: DYRK1A Protein, dyrk Protein, dyrk1 Protein, hp86 Protein, mnb Protein, mnbh Protein, DYRK Protein, DYRK1 Protein, HP86 Protein, MNB Protein, MNBH Protein, MRD7 Protein, 2310043O08Rik Protein, D16Ertd272e Protein, D16Ertd493e Protein, Dyrk Protein, ENSMUSG00000074897 Protein, Gm10783 Protein, Mnbh Protein, Mp86 Protein, mmb Protein, PSK47 Protein, dual specificity tyrosine phosphorylation regulated kinase 1A Protein, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A Protein, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Protein, dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1A S homeolog Protein, DYRK1A Protein, dyrk1a Protein, Dyrk1a Protein, dyrk1a.S Protein

Hintergrund: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5&apos UTR or in the 3&apos coding region. These variants encode at least five different isoforms.

Molekulargewicht: 85.6 kDa

NCBI Accession: NP_001387

Pathways: Mitotic G1-G1/S Phases