COQ6 Protein (His tag)

Produktnummer ABIN2718741

Produktdetails

Target: COQ6 (Coenzyme Q6, Monooxygenase (COQ6))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses COQ6 Protein ist gelabelt mit His tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human COQ6 (N-term HIS tag, transcript variant 1) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the N-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris, pH 8.0, 150 mM NaCl, 10 % glycerol, 1 % Sarkosyl.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: COQ6 (Coenzyme Q6, Monooxygenase (COQ6))

Andere Bezeichnung: Coenzyme q6 Homolog, Monooxygenase (S. Cerevisiae) (Coq6) (COQ6 Produkte)

Synonyme: CGI10 Protein, COQ10D6 Protein, 5930427M12Rik Protein, AW742344 Protein, zgc:153379 Protein, coq6 Protein, coenzyme Q6, monooxygenase Protein, coenzyme Q6 monooxygenase Protein, Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial Protein, coenzyme Q6 monooxygenase L homeolog Protein, COQ6 Protein, Coq6 Protein, coq-6 Protein, coq6 Protein, coq6.L Protein

Hintergrund: The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molekulargewicht: 50.7 kDa

NCBI Accession: NP_872282