GDF7 Protein
-
- Target Alle GDF7 Proteine anzeigen
- GDF7 (Growth Differentiation Factor 7 (GDF7))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
-
Spezies
- Human
-
Quelle
- Escherichia coli (E. coli)
- Applikation
- Antibody Production (AbP), Functional Studies (Func), Protein Interaction (PI), Standard (STD)
- Spezifität
- Optimal preservation of protein structure, post-translational modifications and functions.
- Produktmerkmale
-
- Recombinant human BMP12 / GDF7 protein expressed in E. coli.
- Produced with end-sequenced ORF clone
- Tested for bioactivity.
- Reinheit
- > 95 % as determined by SDS-PAGE and Coomassie blue staining
- Endotoxin-Niveau
- Endotoxin level is <0.1 ng/μg of protein (<1EU/μg).
- Biological Activity Comment
- Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells.
- Top Product
- Discover our top product GDF7 Protein
-
-
- Applikationshinweise
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays
Protein-protein interaction
In vitro biochemical assays and cell-based functional assays - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Buffer
- Lyophilized from a 0.2 μM filtered solution of 20 mM phosphate buffer,100 mM NaCl, pH 7.2
- Handhabung
- Resuspend the protein in the desired concentration in proper buffer
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- GDF7 (Growth Differentiation Factor 7 (GDF7))
- Andere Bezeichnung
- Bmp12,gdf7 (GDF7 Produkte)
- Synonyme
- bmp12 Protein, gdf-7 Protein, gdf16 Protein, gdf16-A Protein, BMP12 Protein, GDF6/7 Protein, growth differentiation factor 7 S homeolog Protein, growth differentiation factor 7 Protein, gdf7.S Protein, GDF7 Protein, Gdf7 Protein
- Hintergrund
- This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma.
- Molekulargewicht
- 28 kDa
- NCBI Accession
- NP_878248
- Pathways
- Tube Formation
-