Aspartate beta Hydroxylase Protein (Transcript Variant 10) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2714994

Produktdetails

Target: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Protein-Typ: Recombinant

Proteineigenschaft: Transcript Variant 10

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Aspartate beta Hydroxylase Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Aspartate beta-hydroxylase (ASPH), transcript variant 10. (transcript variant 10) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

Abstract: ASPH Produkte

Synonyme: AAH Protein, BAH Protein, CASQ2BP1 Protein, HAAH Protein, JCTN Protein, junctin Protein, 2310005F16Rik Protein, 3110001L23Rik Protein, AI848629 Protein, AW261690 Protein, AW561901 Protein, C79816 Protein, cI-37 Protein, aah Protein, bah Protein, jctn Protein, MGC107896 Protein, cb971 Protein, fb69e10 Protein, fc06d04 Protein, fc95a08 Protein, wu:fb69e10 Protein, wu:fc06d04 Protein, wu:fc95a08 Protein, aspartate beta-hydroxylase Protein, aspartate-beta-hydroxylase Protein, aspartate beta-hydroxylase L homeolog Protein, ASPH Protein, Asph Protein, asph Protein, asph.L Protein

Hintergrund: This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.

Molekulargewicht: 32.2 kDa

NCBI Accession: NP_001158226

Pathways: Positive Regulation of Endopeptidase Activity